The androgenic and anabolic-acting steroid Drostanolone is available in the form of propionate (dipropianate) and enanthate–esters that determine the drug’s characteristics. It is known to a wide mass of consumers by the trade names Masteron, Permastril, Metormone, Drolban. Both esters act on the body invariably, but are absorbed into the bloodstream at different rates. The duration of action of enanthate is about 15 days, while the effect of propionate occurs as early as the second to fourth day after injection.

Drostanolone has a moderate anabolic effect but a high androgenic effect, is an aromatase inhibitor, and has no effect on the conversion of testosterone to estrogen. The steroid is a derivative of dihydrotestosterone, has a similar effect and has the chemical formula 2-alpha-dihydrotestosterone propionate. Both enanthate and drostanolone were originally used exclusively as breast cancer therapy, but were discontinued because of the high risk of virilization. Used for athletic purposes, it is usually available in 50 and 100 mg/ml vials.

How does Drostanolone work?

The effect of the steroid drug is manifested by:

  • a moderate diuretic effect;
  • suppression of catabolic processes;
  • increase in strength parameters;
  • pronounced fat-burning effect, scientifically demonstrated, when in the course of
  • of studies “subjects” lost up to 5-7% of fat mass after the course;
  • preservation of muscle volume acquired while taking the steroid, with increased relief, hardness and muscle density.

Athletes take the drug most often during drying, as well as in preparation for competitions.

Drostanolone (Masteron) alone

For maximum effect from the use of enanthate and propionate, bodybuilders take 400 to 500 milligrams of the steroid per week. Increasing the dosage does not lead to a noticeable increase in physiological parameters, but it can cause a quick and rapid development of negative side effects.

The solitary course involves the introduction of propionate three times a week or every other day, while enanthate only once every seven days. The steroid should be started after visiting a sports physician and diagnosing the condition of the whole body. During the entire course it is necessary to undergo appropriate examinations and make changes to the program.

Combined courses with Drostanolone 

The negative aspects of solitary use of the drug are easily eliminated by taking the steroid together with other similar drugs. In its action, Masteron is very similar to androgen receptors.

It is most often used with Winstrol or Oxandrolone. The former shows the greatest efficacy because its interaction with androgen receptors is minimal. It reduces the concentration of sex hormone-binding globulin, that is, it has a synergistic effect.

To increase muscle mass, Masteron is combined with testosterone propionate. In this case, the use of gonadotropin is recommended. This allows the endogenous testosterone level to be compensated. The best compatibility of Drostanolone is demonstrated in combination with drugs such as Trenbolone and Boldenone.

Side Effects.

The pronounced fat-burning property due to a low anabolic index has a downside. It is manifested by an increased risk of androgenic reaction.

The following side effects may accompany the intake of Masteron:

  • increased hair loss;
  • hypertrophy of the prostate;
  • high levels of aggression;
  • acne;
  • virilization.

The steroid has minimal toxic effects on the liver, does not retain fluids in the body, and does not become a cause of increased blood pressure.


An excellent feature of the drug is the prevalence of androgenic activity over anabolic activity. Bodybuilders, as a rule, especially appreciate the fat-burning effect of the steroid. The action is enhanced by taking drugs that offset the androgenic influence. Thus, it is found that the greatest mass loss occurs with combined intake. If the recommended dosage is exceeded, adverse side effects are very likely to occur. Taking the drug is not recommended for women, as the risks of virilization are high. For men, the steroid helps make muscles more prominent, harder, and more pronounced.

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